USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: STK3_HUMAN USC-OGP 2-DE database:  STK3_HUMAN STK3_HUMAN General information about the entry View entry in simple text format Entry name STK3_HUMAN Primary accession number Q13188 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Serine/threonine-protein kinase 3; EC=2.7.11.1; AltName: Full=Mammalian STE20-like protein kinase 2; Short=MST-2; AltName: Full=STE20-like kinase MST2; AltName: Full=Serine/threonine-protein kinase Krs-1; Contains: RecName: Full=Serine/threonine-protein kinase 3 36kDa subunit; Short=MST2/N; Contains: RecName: Full=Serine/threonine-protein kinase 3 20kDa subunit; Short=MST2/C;. Gene name Name=STK3 Synonyms=KRS1, MST2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0053: pI=5.03; Mw=55286 Cross-references UniProtKB/Swiss-Prot Q13188; STK3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name STK3_HUMAN Primary accession number Q13188 Secondary accession number(s) A8K722 B3KYA7 Q15445 Q15801 Q96FM6 Sequence was last modified on  April 26, 2004 (version 2) Annotations were last modified on  March 15, 2017 (version 177) Name and origin of the protein Description RecName: Full=Serine/threonine-protein kinase 3; EC=2.7.11.1; AltName: Full=Mammalian STE20-like protein kinase 2; Short=MST-2; AltName: Full=STE20-like kinase MST2; AltName: Full=Serine/threonine-protein kinase Krs-1; Contains: RecName: Full=Serine/threonine-protein kinase 3 36kDa subunit; Short=MST2/N; Contains: RecName: Full=Serine/threonine-protein kinase 3 20kDa subunit; Short=MST2/C; Gene name Name=STK3 Synonyms=KRS1, MST2 Encoded on Name=STK3; Synonyms=KRS1, MST2 Keywords 3D-structure; Acetylation; Alternative splicing; Apoptosis; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U26424; AAC50386.1; -; mRNA EMBL U60206; AAB17261.1; -; mRNA EMBL AK131363; BAG54769.1; -; mRNA EMBL AK291837; BAF84526.1; -; mRNA EMBL AC016877; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AP002087; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AP003355; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AP003467; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AP003551; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471060; EAW91781.1; -; Genomic_DNA EMBL BC010640; AAH10640.1; -; mRNA EMBL Z25422; CAA80909.1; -; mRNA CCDS CCDS47900.1; -. [Q13188-1]; . CCDS CCDS59108.1; -. [Q13188-2]; . PIR I38212; I38212; . RefSeq NP_001243241.1; NM_001256312.1. [Q13188-2]; . RefSeq NP_006272.2; NM_006281.3. [Q13188-1]; . UniGene Hs.492333; -; . UniGene Hs.738869; -; . PDB 3WWS; X-ray; 2.01 A; A/B/C/D=436-484 PDB 4HKD; X-ray; 1.50 A; A/B/C/D=436-484 PDB 4L0N; X-ray; 1.40 A; A/B/C/D/E/F/G/H/I/J=436-484 PDB 4LG4; X-ray; 2.42 A; A/B/C/D/E/F=16-313 PDB 4LGD; X-ray; 3.05 A; A/B/C/D=9-491 PDB 4OH9; X-ray; 1.70 A; A/B=436-484 PDB 5BRM; X-ray; 2.65 A; G/H/I/J/K/L/M/N/O=371-401 PDB 5DH3; X-ray; 2.47 A; A/B=15-313 PDBsum 3WWS; -; . PDBsum 4HKD; -; . PDBsum 4L0N; -; . PDBsum 4LG4; -; . PDBsum 4LGD; -; . PDBsum 4OH9; -; . PDBsum 5BRM; -; . PDBsum 5DH3; -; . ProteinModelPortal Q13188; -; . SMR Q13188; -; . BioGrid 112664; 89; . DIP DIP-36128N; -; . IntAct Q13188; 81; . MINT MINT-3027356; -; . STRING 9606.ENSP00000390500; -; . BindingDB Q13188; -; . ChEMBL CHEMBL4708; -; . GuidetoPHARMACOLOGY 2219; -; . iPTMnet Q13188; -; . PhosphoSitePlus Q13188; -; . BioMuta STK3; -; . DMDM 46577700; -; . OGP Q13188; -; . EPD Q13188; -; . MaxQB Q13188; -; . PaxDb Q13188; -; . PeptideAtlas Q13188; -; . PRIDE Q13188; -; . DNASU 6788; -; . Ensembl ENST00000419617; ENSP00000390500; ENSG00000104375. [Q13188-1]; . Ensembl ENST00000523601; ENSP00000429744; ENSG00000104375. [Q13188-2]; . GeneID 6788; -; . KEGG hsa:6788; -; . UCSC uc003yio.5; human. [Q13188-1]; . CTD 6788; -; . DisGeNET 6788; -; . GeneCards STK3; -; . HGNC HGNC:11406; STK3; . HPA CAB025316; -; . HPA HPA007120; -; . MIM 605030; gene; . neXtProt NX_Q13188; -; . OpenTargets ENSG00000104375; -; . PharmGKB PA36213; -; . eggNOG KOG0201; Eukaryota; . eggNOG ENOG410XP9G; LUCA; . GeneTree ENSGT00810000125395; -; . HOGENOM HOG000234203; -; . HOVERGEN HBG108518; -; . InParanoid Q13188; -; . KO K04412; -; . OMA KQDSKLK; -; . OrthoDB EOG091G065P; -; . PhylomeDB Q13188; -; . TreeFam TF354217; -; . BRENDA 2.7.11.1; 2681; . Reactome R-HSA-2028269; Signaling by Hippo; . SignaLink Q13188; -; . SIGNOR Q13188; -; . ChiTaRS STK3; human; . GeneWiki STK3; -; . GenomeRNAi 6788; -; . PMAP-CutDB Q13188; -; . PRO PR:Q13188; -; . Proteomes UP000005640; Chromosome 8; . Bgee ENSG00000104375; -; . CleanEx HS_STK3; -; . ExpressionAtlas Q13188; baseline and differential; . Genevisible Q13188; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; . GO GO:0043234; C:protein complex; IDA:MGI; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0000287; F:magnesium ion binding; IDA:UniProtKB; . GO GO:0046983; F:protein dimerization activity; ISS:UniProtKB; . GO GO:0004672; F:protein kinase activity; TAS:ProtInc; . GO GO:0043539; F:protein serine/threonine kinase activator activity; TAS:BHF-UCL; . GO GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB; . GO GO:0004702; F:signal transducer; downstream of receptor; with serine/threonine kinase activity IBA:GO_Central . GO GO:0006915; P:apoptotic process; TAS:UniProtKB; . GO GO:0060706; P:cell differentiation involved in embryonic placenta development; IEA:Ensembl; . GO GO:0007417; P:central nervous system development; IEA:Ensembl; . GO GO:0003157; P:endocardium development; IEA:Ensembl; . GO GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl; . GO GO:0035329; P:hippo signaling; TAS:UniProtKB; . GO GO:0035556; P:intracellular signal transduction; IDA:UniProtKB; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:BHF-UCL; . GO GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl; . GO GO:0046621; P:negative regulation of organ growth; IEA:Ensembl; . GO GO:0001841; P:neural tube formation; IEA:Ensembl; . GO GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB; . GO GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl; . GO GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl; . GO GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl; . GO GO:0032092; P:positive regulation of protein binding; IDA:MGI; . GO GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl; . GO GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IGI:MGI; . GO GO:0060215; P:primitive hemopoiesis; IEA:Ensembl; . GO GO:0006468; P:protein phosphorylation; IDA:UniProtKB; . GO GO:0050821; P:protein stabilization; IMP:MGI; . GO GO:0060800; P:regulation of cell differentiation involved in embryonic placenta development; IEA:Ensembl; . GO GO:0007165; P:signal transduction; TAS:ProtInc; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR024205; Mst1_SARAH_domain; . InterPro IPR000719; Prot_kinase_dom; . InterPro IPR017441; Protein_kinase_ATP_BS; . InterPro IPR011524; SARAH_dom; . Pfam PF11629; Mst1_SARAH; 1; . Pfam PF00069; Pkinase; 1; . SMART SM00220; S_TKc; 1; . SUPFAM SSF56112; SSF56112; 1; . PROSITE PS00107; PROTEIN_KINASE_ATP; 1; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; . PROSITE PS50951; SARAH; 1; .

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